Fischer Oxazole Synthesis
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Fischer Oxazole Synthesis. Comprehensive Organic Name Reactions and Reagents. 234:1076–1079.
- Published Online: 15 SEP 2010
The synthesis of oxazole derivatives by treatment of equimolar amounts of aldehyde cyanohydrin and aromatic aldehyde in anhydrous ether with dry hydrochloride is known as the Fischer oxazole synthesis or Fischer synthesis. This method is found suitable for the preparation of 2,5-diaryloxazoles. Some minor byproducts have also been reported to form in this reaction. The modifications of this reaction include the reaction between aroyl cyanide and aromatic aldehyde in the presence of HCl gas and the reaction of nitrile with aromatic aldehyde, HCl and SOCl2.