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Fischer-Speier Esterification

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr239

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Fischer-Speier Esterification. Comprehensive Organic Name Reactions and Reagents. 239:1095–1097.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of ester by refluxing carboxylic acid with an excess amount of alcohol in the presence of an acidic catalyst (e.g., HCl) is known as the Fischer–Speier esterification. The azeotropic refluxing and acidic catalyst are found to facilitate the reaction, often by passing dry HCl gas into the solution. The mechanism of the sulfuric acid–promoted esterification has also summarized. The p-toluenesulfonic acid (TsOH) is often used when dry HCl is not available.

Keywords:

  • carboxylic acid;
  • methyl esters;
  • azeotropic refluxing;
  • p-toluenesulfonic acid (TsOH)