Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Gassman Reaction. Comprehensive Organic Name Reactions and Reagents. 1198–1201.
- Published Online: 15 SEP 2010
This reaction is a multistep preparation of ortho-alkylated anilines by sequential treatment of the anilines with tert-butyl hypochlorite, dialkylsulfide, and triethylamine followed by Raney nickel desulfurization and is generally referred to as the Gassman reaction. This reaction can be adapted to prepare the anilines with vinyl, formyl, and benzyl groups at the ortho-position. This reaction has been improved by using sulfuryl chloride as the chlorination reagent.
- tert-butyl hypochlorite;
- N-t-butyl-N-chloro anilines;
- sulfuryl chloride;