Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Gattermann-Koch Formylation. Comprehensive Organic Name Reactions and Reagents. 266:1209–1212.
- Published Online: 15 SEP 2010
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The preparation of aromatic aldehydes by the treatment of aromatic compounds with CO and HCl in the presence of AlCl3 and cuprous chloride, by which CO and HCl behave like the hypothetical formyl chloride and react in a fashion similar to other acyl chlorides, is generally known as the Gattermann–Koch formylation. It is known that this reaction can be carried out in two major types of conditions: at atmospheric pressure of CO with Cu2Cl2 present and at high-pressure in absence of Cu2Cl2, in which the optimal temperature for high-pressure synthesis of benzaldehyde is 35°C. This reaction is the major process for the synthesis of aromatic aldehydes in industry.
- cuprous chloride;
- superacid systems;