(Gould-Jacobs Quinoline Synthesis)
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Gould-Jacobs Reaction. Comprehensive Organic Name Reactions and Reagents. 276:1252–1255.
- Published Online: 15 SEP 2010
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The synthesis of 4-hydroxyquinolines from anilines and diethyl ethoxymethylenemalonate involving the condensation to anilinomethylenemalonate, cyclo-acylation to quinolin-4-one nucleus, and subsequent hydrolysis and decarboxylation is generally referred to as the Gould–Jacobs reaction. This reaction works well for anilines with electron-donating groups at the meta-position. This reaction is very useful for preparing 4-hydroxyquinoline derivatives.
- diethyl ethoxymethylenemalonate;