Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Hammick Reaction. Comprehensive Organic Name Reactions and Reagents. 292:1314–1316.
- Published Online: 15 SEP 2010
The synthesis of α-pyridylcarbinols by the decarboxylation of picolinic acid with excess amount of carbonyl compounds is generally known as the Hammick reaction. It is also referred to as the Hammick coupling. The reaction involves the carbonyl compounds coupling with the heterocyclic moiety upon decarboxylation. The reaction includes the three kinds of intermediates, which are favored by certain experimental results. Furthermore, the intermediate can also react with other electrophiles instead of carbonyl compounds. This reaction has been used in the preparation of pyridylcarbinols.
- neutral solvents;
- acidic solvents;
- Schiff bases