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Hansley-Prelog Acyloin Condensation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr293

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Hansley-Prelog Acyloin Condensation. Comprehensive Organic Name Reactions and Reagents. 293:1317–1320.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

This reaction has been used to prepare cyclic acyloins of 8 or more carbon atoms from the reaction of colloidal sodium with esters of saturated or unsaturated dicarboxylic acids in high dilution and resulted cyclic acyloins can be further converted into cyclic ketones with the same carbon numbers by the reduction of zinc and hydrochloric acid in acetic acid. This reaction involves the radical mechanism. This reaction has been used for the preparation of medium to large cyclic ketones.

Keywords:

  • cyclic acyloins;
  • colloidal dispersion;
  • radical mechanism;
  • cyclic ketones