Hantzsch Dihydropyridine Synthesis
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Hantzsch Dihydropyridine Synthesis. Comprehensive Organic Name Reactions and Reagents. 294:1321–1325.
- Published Online: 15 SEP 2010
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The synthesis of dihydropyridine dicarboxylate by condensation of an aldehyde with 2 eq. β-keto ester in the presence of ammonia is known as the Hantzsch dihydropyridine synthesis and the product formed dihydropyridine dicarboxylate is called the Hantzsch ester. The Hantzsch ester, as a calcium antagonist, has important applications in drug design. Various modifications have been applied for this reaction and prepare unsymmetrical 1,4-dihydropyridine and 3,5-dicyanodihydropyridine. Besides this, this reaction has been adapted to occur under microwave irradiation.
- β-keto ester;
- Hantzsch ester;
- dihydropyridine dicarboxylate;
- calcium antagonist