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Hantzsch Dihydropyridine Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr294

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Hantzsch Dihydropyridine Synthesis. Comprehensive Organic Name Reactions and Reagents. 294:1321–1325.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of dihydropyridine dicarboxylate by condensation of an aldehyde with 2 eq. β-keto ester in the presence of ammonia is known as the Hantzsch dihydropyridine synthesis and the product formed dihydropyridine dicarboxylate is called the Hantzsch ester. The Hantzsch ester, as a calcium antagonist, has important applications in drug design. Various modifications have been applied for this reaction and prepare unsymmetrical 1,4-dihydropyridine and 3,5-dicyanodihydropyridine. Besides this, this reaction has been adapted to occur under microwave irradiation.

Keywords:

  • β-keto ester;
  • Hantzsch ester;
  • dihydropyridine dicarboxylate;
  • calcium antagonist