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Haworth Methylation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr298

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Haworth Methylation. Comprehensive Organic Name Reactions and Reagents. 1338–1341.

Publication History

  1. Published Online: 15 SEP 2010

Abstract

Haworth methylation has been used to prepare methylated methyl glycoside from methyl glycosides with dimethyl sulfate and 30% sodium hydroxide. It is used to elucidate the sugar structures, including the linkages between monosaccharide units in disaccharides or oligosaccharides and the ring structures. Under favorable conditions, the deprotonation reaction takes place; the sodium hydroxide is strong enough to deprotonate the hydroxyl groups on glycosides. It has been modified by means of the treatment of glycosides with carbon tetrachloride solution of methyl sulfate and 60% sodium hydroxide. It has wide application in carbohydrate chemistry, for the structural analysis of carbohydrates.

Keywords:

  • deprotonation;
  • glycosides;
  • carbohydrate chemistry;
  • sodium hydroxide