Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Haworth Methylation. Comprehensive Organic Name Reactions and Reagents. 1338–1341.
- Published Online: 15 SEP 2010
Haworth methylation has been used to prepare methylated methyl glycoside from methyl glycosides with dimethyl sulfate and 30% sodium hydroxide. It is used to elucidate the sugar structures, including the linkages between monosaccharide units in disaccharides or oligosaccharides and the ring structures. Under favorable conditions, the deprotonation reaction takes place; the sodium hydroxide is strong enough to deprotonate the hydroxyl groups on glycosides. It has been modified by means of the treatment of glycosides with carbon tetrachloride solution of methyl sulfate and 60% sodium hydroxide. It has wide application in carbohydrate chemistry, for the structural analysis of carbohydrates.
- carbohydrate chemistry;
- sodium hydroxide