Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Helferich Condensation. Comprehensive Organic Name Reactions and Reagents. 303:1363–1366.
- Published Online: 15 SEP 2010
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The direct synthesis of acetylated phenyl glycosides from the fusion of monosaccharide pentaacetate and phenol in the presence of an acidic catalyst is generally referred to as the Helferich condensation. It has been reported that the reaction has been improved by carrying out the condensation under vacuum where released acetic acid is removed immediately from the reaction system or in the presence of acetic acid and acetic anhydride. The study finds that this reaction is not suitable for the less common or harder to obtain phenols. This reaction has been applied for the preparation of aryl glycosides.
- acidic catalyst