Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Hinsberg Reaction. Comprehensive Organic Name Reactions and Reagents. 316:1418–1421.
- Published Online: 15 SEP 2010
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This reaction is the preparation of sulfonamides involving the treatment of primary or secondary amines with arenesulfonyl chloride, the further alkylation of resulting sulfonamides from primary amines, and the hydrolysis of sulfonamides into primary or secondary amines. The arenesulfonyl chloride is used to differentiate the types of amines (i.e., primary, secondary, and tertiary amines) and protect the amino group. Because the formed sulfonamides are very stable, different methods have been tested to hydrolyze the sulfonamides. This reaction has been modified to use p-phenylazobenzenesulfonyl chloride to react with amines to monitor the reaction.
- Hinsberg test;
- p-phenylazobenzenesulfonyl chloride;
- amino groups