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Jacobsen-Katsuki Epoxidation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr343

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Jacobsen-Katsuki Epoxidation. Comprehensive Organic Name Reactions and Reagents. 343:1534–1541.

Publication History

  1. Published Online: 15 SEP 2010

Abstract

The Jacobsen and Katsuki have reported the improvement of olefin epoxidation, using a sophisticated chiral salen ligand for manganese complexes, which resulted in high enantioselectivity. They extensively studied different facets of this reaction to convert it into one of the most useful and widely applicable methods for the epoxidation of unfunctionalized olefins. Thus, this reaction is referred to as the Jacobsen-Katsuki epoxidation. It is usually executed in dichloromethane or acetonitrile. The present study represents the features of the Jacobsen's catalysts and Katsuki's catalysts, which have been used in the epoxidation reaction. This reaction is a strongly electrophilic reaction and has been extended to occur in ionic liquid. This reaction has been used for the highly selective hydrolytic kinetic resolution of epoxides especially for the asymmetric epoxidation of olefins.

Keywords:

  • Jacobsen's catalysts;
  • Katsuki's catalysts;
  • olefins;
  • asymmetric epoxidation