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Kabachnik-Fields Reaction

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr353

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Kabachnik-Fields Reaction. Comprehensive Organic Name Reactions and Reagents. 353:1588–1592.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

A one-pot synthesis of α-amino phosphonate via the three-component coupling of aldehyde (or ketone), an amine, and a dialkylphosphite is generally referred to as the Kabachnik–Fields reaction. It has been reported ketones undergo the coupling more readily than aldehydes, especially for aliphatic ketones that react vigorously. Besides this several other reaction conditions have been discussed to achieve the optimal yields. This reaction has been applied for the preparation of α-amino phosphonates, which are useful for chelating agents.

Keywords:

  • aldehyde;
  • anhydrous ammonia;
  • α-amino phosphonates;
  • dialkyl phosphite