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Knorr Pyrazole Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr363

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Knorr Pyrazole Synthesis. Comprehensive Organic Name Reactions and Reagents. 363:1631–1633.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The preparation of pyrazole derivatives from 1,3-dicarbonyl compounds and hydrazines is known as the Knorr pyrazole synthesis. The study finds that similarly pyrazole derivatives can also be prepared from hydrazines and equivalent molecules of 1,3-dicarbonyl compounds. The study represents other reactions, such as β-carbonyl aldehyde with hydrazine and β-carbonyl ester with hydrazine to understand the mechanism of the reaction. This reaction has general application in the preparation of pyrazole derivatives.

Keywords:

  • hydrazines;
  • pyrazole derivatives;
  • tautomers;
  • β-carbonyl aldehyde