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Knorr Pyrrole Synthesis

(Knorr Pyrrole Reaction)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr364

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Knorr Pyrrole Synthesis. Comprehensive Organic Name Reactions and Reagents. 364:1634–1637.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of pyrrole derivatives by the condensation of α-amino ketones with carbonyl compounds containing active α-methylene groups is generally referred to as the Knorr pyrrole synthesis. This reaction is highly regioselective and always gives high yields of pyrrole derivatives. The study presents various conditions through which we can prevent the environmental hazards from this reaction when carried out on large scale. On the other hand, it has also been reported that even more pyrrole derivatives could be yielded if α-amino ketone hydrochlorides are used directly rather than generated in situ.

Keywords:

  • pyrrole derivatives;
  • α-methylene groups;
  • carbonyl group;
  • α-amino ketone hydrochlorides