Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Koch-Haaf Carboxylation. Comprehensive Organic Name Reactions and Reagents. 366:1642–1645.
- Published Online: 15 SEP 2010
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The formation of tertiary carboxylic acids or esters by treatment of alcohols or alkenes with anhydrous formic acid that functions as both an acidic catalyst and a source of carbon monoxide is generally referred to as the Koch–Haaf carboxylation.
This reaction has been quickly modified and utilizes for an industrial production of carboxylic acid. The carboxylation of alcohols occurs in two steps. Several Brønsted and Lewis acids have been found to catalyze this reaction and BF3 is the most effective catalyst. This reaction has important application in industry for producing carboxylic acids.
- Brønsted acids;
- Lewis acids;
- carboxylic acids;
- aryl esters