Standard Article

Koch-Haaf Carboxylation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr366

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Koch-Haaf Carboxylation. Comprehensive Organic Name Reactions and Reagents. 366:1642–1645.

Publication History

  1. Published Online: 15 SEP 2010

Chemistry Terms

Choose one or more boxes to highlight terms.

Abstract

The formation of tertiary carboxylic acids or esters by treatment of alcohols or alkenes with anhydrous formic acid that functions as both an acidic catalyst and a source of carbon monoxide is generally referred to as the Koch–Haaf carboxylation.

This reaction has been quickly modified and utilizes for an industrial production of carboxylic acid. The carboxylation of alcohols occurs in two steps. Several Brønsted and Lewis acids have been found to catalyze this reaction and BF3 is the most effective catalyst. This reaction has important application in industry for producing carboxylic acids.

Keywords:

  • Brønsted acids;
  • Lewis acids;
  • carboxylic acids;
  • aryl esters