Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Lander Rearrangement. Comprehensive Organic Name Reactions and Reagents. 384:1713–1716.
- Published Online: 15 SEP 2010
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The thermal conversion of alkyl imidates (also known as imino ethers) into N-alkyl amides in the presence of an alkylting agent is generally referred to as the Lander rearrangement. Such trend of alkyl group replacement has been postulated as early as in 1897 for the conversion of 2-methoxyquinoline or 2-ethoxyquinoline into N-methyl-2-quinolone with excess methyl iodide. The study finds that this rearrangement also occurs smoothly in the absence of an alkylting agent. This reaction is used to convert methoxypyridines into N-methylpyridones.
- alkyl imidates;