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Leuckart Reaction

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr390

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Leuckart Reaction. Comprehensive Organic Name Reactions and Reagents. 390:1737–1742.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

This reaction is the reductive amination of carbonyl compounds (i.e., aldehydes and ketones) with ammonium formate or the combination of formic acid and formamides to give primary, secondary, or tertiary amines and is generally known as the Leuckart reaction. In this reaction, formic acid and formates function as reducing reagents or hydride donors, so that tertiary amine can be prepared. Several reaction conditions have been discussed, which affect the yield of the corresponding amines, such as water content, temperature, etc. This reaction is useful for the preparation of primary, secondary, and tertiary amines.

Keywords:

  • formamide;
  • ammonium formate;
  • magnesium chloride;
  • benzophenone