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Lobry de Bruyn-Alberda van Ekenstein Transformation

(Lobry de Bruyn-van Ekenstein Transformation)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr396

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Lobry de Bruyn-Alberda van Ekenstein Transformation. Comprehensive Organic Name Reactions and Reagents. 396:1763–1766.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

Lobry de Bruyn–Alberda van Ekenstein rearrangement involves the reciprocal interconversion of carbohydrates into their isomers in an alkaline solution through the enediolic intermediate. It is a glycochemical reaction catalyzed by hydroxide, irrespective of the counterions, and depends only on the base concentration and temperature. The reaction mechanism takes place via the transformation reactions. This reaction is used in the preparation of carbohydrate isomers on the basis of available carbohydrate molecules.

Keywords:

  • carbohydrates;
  • retro-aldol condensation;
  • glucose-6-phosphate;
  • enediolic intermediate