Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. MacDonald-Fischer Degradation. Comprehensive Organic Name Reactions and Reagents. 401:1787–1790.
- Published Online: 15 SEP 2010
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The degradation of hexoses into pentoses involves several steps: formation of dithioacetal, oxidation to unsaturated disulfone by means of perphthalic acid, hydrazine treatment, and benzaldehyde splitting of the corresponding hydrazone. The whole process is known as the MacDonald–Fischer degradation. This reaction has been used to degrade the carbohydrates and study the structure and stereochemistry of carbohydrates.