Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Malaprade Reaction. Comprehensive Organic Name Reactions and Reagents. 406:1807–1810.
- Published Online: 15 SEP 2010
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The oxidation of adjacent diols with periodic acid or its salt in aqueous solution is generally known as the Malaprade reaction. Several solvents have been used to increase the solubility of organic substrates and the reaction proceeds faster under acidic conditions. This reaction has been further extended to the cleavage of α-hydroxy carbonyl compounds, 1,2-dicarbonyl compounds, α-amino alcohols, α-amino acids, and polyhydroxy alcohols and successfully applied for structural analysis.
- periodic acid;
- 1,2-dicarbonyl compounds;
- polyhydroxy alcohols;
- formic acid