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Malaprade Reaction

(Malaprade Oxidation)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr406

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Malaprade Reaction. Comprehensive Organic Name Reactions and Reagents. 406:1807–1810.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The oxidation of adjacent diols with periodic acid or its salt in aqueous solution is generally known as the Malaprade reaction. Several solvents have been used to increase the solubility of organic substrates and the reaction proceeds faster under acidic conditions. This reaction has been further extended to the cleavage of α-hydroxy carbonyl compounds, 1,2-dicarbonyl compounds, α-amino alcohols, α-amino acids, and polyhydroxy alcohols and successfully applied for structural analysis.

Keywords:

  • periodic acid;
  • 1,2-dicarbonyl compounds;
  • polyhydroxy alcohols;
  • formic acid