Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Mattox-Kendall Reaction. Comprehensive Organic Name Reactions and Reagents. 414:1845–1848.
- Published Online: 15 SEP 2010
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The synthesis of α,β-unsaturated ketones by means of dehydrobromination of phenylhydrazone of a semicarbazone derivative of the corresponding α-bromoketone is known as the Mattox–Kendall reaction. This reaction has been used for the transformation of steroids and also applicable to cyclic α-bromo ketones or alicyclic ketones. On the other hand, this reaction does not work for methyl 4β-bromo-3-ketocholanate. This reaction has been modified for the direct elimination of hydrogen bromide by using collidine as a base.
- α,β-unsaturated ketones;
- α-bromo ketone