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McFadyen-Stevens Reaction

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr416

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. McFadyen-Stevens Reaction. Comprehensive Organic Name Reactions and Reagents. 416:1853–1855.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of aromatic or heterocyclic aldehydes from base-catalyzed thermal decomposition of acylbenzenesulfonylhydrazides in ethylene glycol is generally referred to as the McFadyen–Stevens reaction. The optimal conditions for this reaction have been discussed for the synthesis of the final product, such as use of one equivalent of base in the presence of a solid powder. The decomposition of acylbenzenesulfonylhydrazide of aliphatic carboxylic acids to aldehydes holds similar mechanistic characters. This reaction has been applied in the conversion of carboxylic acid into corresponding aldehydes.

Keywords:

  • dimethylacetamide (DMA);
  • acylbenzenesulfonylhydrazides;
  • aprotic solvent;
  • charcoal