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Meerwein Arylation

(Meerwein Reaction)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr419

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Meerwein Arylation. Comprehensive Organic Name Reactions and Reagents. 419:1866–1870.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

It is a copper salt-initiated reaction between an aryl diazonium salt and an alkene (or an alkyne, arene) that is activated by an electron-withdrawing group and is generally referred to as the Meerwein arylation. The mechanistic features of the reaction have been discussed and it has been observed that few factors strongly influence this reaction, such as the substrate, solvent, temperature, pH, and catalyst. The optimal reaction condition has also been represented for this reaction and CaO rather than NaOAc is added in some of the cases to neutralize the generated HCl. Furthermore, this reaction has been modified and has been applied for the preparation of substituted styrene derivatives and aryl derivatives.

Keywords:

  • aryl diazonium salt;
  • p-chlorobenzenediazonium chloride;
  • CuCl2;
  • CaO