(Negishi Coupling, Negishi Reaction)
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Negishi Cross-Coupling. Comprehensive Organic Name Reactions and Reagents. 456:2029–2034.
- Published Online: 15 SEP 2010
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The palladium or nickel-catalyzed coupling between an aryl or alkenylzinc, zirconium or aluminum reagent and an alkenyl or aryl halide or triflate; specifically, it is an organozinc reagent-mediated coupling with an alkenyl or aryl halides/triflates and is generally known as the Negishi cross-coupling. This reaction can tolerate a variety of functional groups and commonly catalyzed by a transition metal of palladium or nickel with triaryl or trialkyl phosphines as ligands. It has also been observed that the ligand has a substantial impact on the course of the Negishi cross-coupling. This reaction has been modified for various conditions and is applied for the formation of C-C bonds.
- aryl halide;
- Pd-N-heterocyclic carbene (NHC)