Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Nenitzescu Synthesis. Comprehensive Organic Name Reactions and Reagents. 458:2038–2041.
- Published Online: 15 SEP 2010
Choose one or more boxes to highlight terms.
The formation of an α,β-unsaturated ketone directly by aluminum chloride-promoted acylation of alkenes with acyl halides is generally referred to as the Nenitzescu synthesis. The study finds the formation of the saturated ketones is probably caused by the intermolecular hydrogen transfer from the solvent. It has been observed that under various reaction conditions, the Nenitzescu synthesis is often complicated with the formation of β-halo ketones, β,γ-enones, or β-acyloxy ketones and this complication can be overcome by an aluminum chloride-promoted acylation with vinyl mercuric chloride. This reaction is useful in the preparation of α,β-unsaturated ketones.
- 4-phenyl cyclohexyl methyl ketone;
- β-halo ketones;
- vinyl mercuric chloride