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Noyori Hydrogenation

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr466

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Noyori Hydrogenation. Comprehensive Organic Name Reactions and Reagents. 466:2072–2075.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The ruthenium or rhodium complex-catalyzed reduction of the carbonyl or alkenyl group by hydrogen with high efficiency and excellent enantioselectivity is generally known as the Noyori hydrogenation. In this reaction, hydrogen is activated by binding to the ruthenium atom and subsequent attacking from a Brønsted base, such as alkoxide. It has been reported that the enantioselectivity arises from the specific recognition of the re or si face of the carbonyl group, and the combination of HCO2H/Et3N or HCO2Na/n-Bu4NBr in H2O/CH2Cl2 can be used as the hydrogen source. This reaction has been modified to use a self-supported catalyst and is very useful for the enantiomeric hydrogenation of ketones and olefins.

Keywords:

  • ruthenium complex;
  • Brønsted base;
  • alkoxide;
  • isopropanol