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Nysted Reagent

(Nysted Methylenation)

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr468

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Nysted Reagent. Comprehensive Organic Name Reactions and Reagents. 468:2081–2083.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The cyclo-dibromo-di-m-methylene-(m-tetrahydrofuran)-trizinc is known as the Nysted reagent. This reagent is prepared by treatment of dibromomethane with activated zinc-lead couple or hydrogen chloride-activated zinc dust in THF. This reagent is useful for converting a carbonyl group into a methylene group, and such transformation is known as the Nysted methylenation or Nysted olefination. The study finds that this reagent is superior to the Tebbe reagent.

Keywords:

  • dibromomethane;
  • MOM acetal;
  • THF;
  • TiCl4