Paal-Knorr Furan Synthesis
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Paal-Knorr Furan Synthesis. Comprehensive Organic Name Reactions and Reagents. 474:2104–2106.
- Published Online: 15 SEP 2010
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This reaction is an acid-catalyzed transformation of 1,4-dicarbonyl compounds into furan derivatives and is generally referred to as the Paal–Knorr reaction or Paal–Knorr synthesis. Several acidic catalysts have been reported to include in this reaction, such as P2O5 (in ethanol),4 p-TsOH or ZnCl2 (in Ac2O)5 and polyphosphoric acid. The cyclization rate of the meso-diastereomers and the dl-isomers.has been compared. This reaction has been modified by the cyclization of 2-ene-1,4-diones or 2-yne-1,4-diones under microwave irradiation. This reaction is an important reaction for the preparation of furan derivatives.
- furan derivatives;
- polyphosphoric acid;
- 1,4-dicarbonyl compounds;
- polyphosphoric acid