Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Parham Cyclization. Comprehensive Organic Name Reactions and Reagents. 477:2114–2117.
- Published Online: 15 SEP 2010
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The synthesis of aryl or heteroaryl ring fused carbocylces or heterocycles through the intramolecular reaction between a side chain electrophile and an aryl or heteroaryllithium generated from lithium-halogen exchange is generally known as the Parham cyclization. This reaction is useful for the synthesis of alkaloids.
- intramolecular electrophiles;
- heteroaryl fused carbocycles;