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Parham Cyclization

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr477

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Parham Cyclization. Comprehensive Organic Name Reactions and Reagents. 477:2114–2117.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The synthesis of aryl or heteroaryl ring fused carbocylces or heterocycles through the intramolecular reaction between a side chain electrophile and an aryl or heteroaryllithium generated from lithium-halogen exchange is generally known as the Parham cyclization. This reaction is useful for the synthesis of alkaloids.

Keywords:

  • alkaloids;
  • intramolecular electrophiles;
  • heteroaryl fused carbocycles;
  • heteroaryllithium