Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Peterson Olefination. Comprehensive Organic Name Reactions and Reagents. 491:2176–2181.
- Published Online: 15 SEP 2010
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The two-step synthesis of olefin involving the addition of an α-silyl carbanion to a carbonyl compound to form β-silyl alcohol and the elimination of silol is generally known as the Peterson olefination. This reaction has many advantages. This reaction has been modified by the use of an α-silyl selenoacetamide to generate E-olefins. Furthermore, an asymmetric version of this reaction has been developed by the use of an external chiral tridentate amino diether as a chiral ligand. This reaction has been generally applied in the preparation of olefins.
- α-silyl selenoacetamide;
- Wittig reaction;
- α-silyl carbanion