Petrenko-Kritschenko Piperidone Synthesis
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Petrenko-Kritschenko Piperidone Synthesis. Comprehensive Organic Name Reactions and Reagents. 492:2182–2184.
- Published Online: 15 SEP 2010
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The preparation of piperidone via a double Mannich reaction from acetonedicarboxylic ester, two equivalents of aldehyde, and ammonia (or a primary amine) is generally referred to as the Petrenko–Kritschenko piperidone synthesis. The study finds that the use of ammonia acetate in acetic acid as the reaction medium is useful for the preparation of piperidone derivatives.
- acetic acid;
- piperidone derivatives;
- Mannich reaction