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Petrenko-Kritschenko Piperidone Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr492

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Petrenko-Kritschenko Piperidone Synthesis. Comprehensive Organic Name Reactions and Reagents. 492:2182–2184.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The preparation of piperidone via a double Mannich reaction from acetonedicarboxylic ester, two equivalents of aldehyde, and ammonia (or a primary amine) is generally referred to as the Petrenko–Kritschenko piperidone synthesis. The study finds that the use of ammonia acetate in acetic acid as the reaction medium is useful for the preparation of piperidone derivatives.

Keywords:

  • ammonia;
  • acetic acid;
  • piperidone derivatives;
  • Mannich reaction