Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Radziszewski Reaction. Comprehensive Organic Name Reactions and Reagents. 518:2293–2297.
- Published Online: 15 SEP 2010
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The synthesis of an imidazole derivative by the condensation of an α-dicarbonyl compound (e.g., glyoxal), an aldehyde and two equivalents of dry ammonia in alcohol and is generally known as the Radziszewski reaction. This reaction in general gives poor yields and suffers from some side reactions. This reaction is useful for the preparation of imidazoles with a substituent at position 2 from adjacent di-carbonyl compounds. This reaction has been modified through the condensation of α-acetoacetone, cupric acetate, and aqueous ammonia to afford imidazoles substantially high yields. This reaction is very useful for the preparation of imidazole derivatives.