Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Thorpe-Ziegler Cyclization. Comprehensive Organic Name Reactions and Reagents. 620:2766–2769.
- Published Online: 15 SEP 2010
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The Thorpe–Ziegler cyclization is a base-catalyzed intramolecular condensation of α,ω-dinitriles to form cyclic ketones and has been employed especially for the preparation of macrocyclic ketones by a high dilution technique. Occasionally, this reaction is also known as the Thorpe–Ziegler addition. This reaction has been extended to the intramolecular condensation of ω-cyano sulfones. Currently, this reaction has been used for the preparation of heterocycles.
- alkyl nitriles;
- macrocyclic ketones;
- sodium ethoxide;