Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Trost Desymmetrization. Comprehensive Organic Name Reactions and Reagents. 627:2797–2802.
- Published Online: 15 SEP 2010
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Desymmetrization means to remove a symmetric element from the substrate and it may take place in the presence of an enzyme or a nonenzymatic catalyst. Among the known nonenzymatic desymmetrization processes, the most common one is the palladium-catalyzed desymmetrization of meso-2-ene-1,4-diols. Overall, the desymmetrization of meso-compounds is getting popular because it can offer asymmetric synthons of high value via a limited number of steps. Many desymmtrization protocols have been summarized. This type of transformation has wide application in organic synthesis.
- arylboronic acid;
- cinchona alkaloid;