Standard Article

Ullmann Acridine Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr635

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Ullmann Acridine Synthesis. Comprehensive Organic Name Reactions and Reagents. 635:2838–2841.

Publication History

  1. Published Online: 15 SEP 2010

Chemistry Terms

Choose one or more boxes to highlight terms.

Abstract

The preparation of acridine derivatives by means of the treatment of N-arylanthranilic acid with an acylating agent, such as polyphosphoric acid (PPA), followed by reduction and dehydration is generally referred to as the Ullmann acridine synthesis. In this reaction, the acylating reagents have been used, such as POCl3, H2SO4, (CF3CO)2O, HCl, TFA, or PPA. Furthermore, the acridones can be converted into the corresponding acridines via the reduction process and react with Grignard reagent followed by dehydration to form 9-substituted acridines. This reaction is useful for the preparation of acridine derivatives.

Keywords:

  • acridones;
  • Grignard reagent;
  • N-arylanthranilic acid;
  • polyphosphoric acid