Urech Hydantoin Synthesis
Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Urech Hydantoin Synthesis. Comprehensive Organic Name Reactions and Reagents. 639:2856–2859.
- Published Online: 15 SEP 2010
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The formation of hydantoins by means of the treatment of α-amino acids with potassium cyanate in aqueous solution and is generally referred to as the Urech hydantoin synthesis. This reaction is a two-step process. The study finds that the α-amino acid is water soluble, whereas hydantoins are only slightly soluble in water. This reaction has been used to separate amino acids after the hydrolysis of protein; the resulting hydantoins are then converted into the α-amino acids. This reaction has been modified by the reaction of potassium cyanate with α-amino nitriles in glacial acetic acid. This reaction has been applied for the preparation of hydantoins.
- 5-substituted hydantoins;
- glacial acetic acid;
- hydantoic acid;
- α-amino acids