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Urech Hydantoin Synthesis

Published Online: 15 SEP 2010

DOI: 10.1002/9780470638859.conrr639

Comprehensive Organic Name Reactions and Reagents

Comprehensive Organic Name Reactions and Reagents

How to Cite

2010. Urech Hydantoin Synthesis. Comprehensive Organic Name Reactions and Reagents. 639:2856–2859.

Publication History

  1. Published Online: 15 SEP 2010

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Abstract

The formation of hydantoins by means of the treatment of α-amino acids with potassium cyanate in aqueous solution and is generally referred to as the Urech hydantoin synthesis. This reaction is a two-step process. The study finds that the α-amino acid is water soluble, whereas hydantoins are only slightly soluble in water. This reaction has been used to separate amino acids after the hydrolysis of protein; the resulting hydantoins are then converted into the α-amino acids. This reaction has been modified by the reaction of potassium cyanate with α-amino nitriles in glacial acetic acid. This reaction has been applied for the preparation of hydantoins.

Keywords:

  • 5-substituted hydantoins;
  • glacial acetic acid;
  • hydantoic acid;
  • α-amino acids