Published Online: 15 SEP 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Comprehensive Organic Name Reactions and Reagents
How to Cite
2010. Wichterle Reaction. Comprehensive Organic Name Reactions and Reagents. 669:3003–3007.
- Published Online: 15 SEP 2010
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This reaction is a modification of the Robinson annulation in which 1,3-dichloro-cis-2-butene is applied as the equivalent of methyl vinyl ketone to avoid the potentially undesirable condensation and polymerization during the step of the Michael addition, and is generally referred to as the Wichterle reaction. The most important modification for this reaction is the application of 2-trimethylsilyl-4-iodo-2-cis-butene for the annulation. This reaction has been applied for preparation of fused cyclic compounds.
- γ-chlorocrotyl derivatives;
- methyl vinyl ketone;
- sulfuric acid