Chapter 9. Controlled Release Using Bilayer Osmotic Tablet Technology: Reducing Theory to Practice

  1. Hong Wen2 and
  2. Kinam Park3
  1. Sheri L. Shamblin

Published Online: 23 AUG 2010

DOI: 10.1002/9780470640487.ch9

Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice

Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice

How to Cite

Shamblin, S. L. (2010) Controlled Release Using Bilayer Osmotic Tablet Technology: Reducing Theory to Practice, in Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice (eds H. Wen and K. Park), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640487.ch9

Editor Information

  1. 2

    Pharmaceutical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA

  2. 3

    Departments of Biomedical Engineering and Pharmaceutics, Purdue University School of Pharmacy, West Lafayette, IN, USA

Author Information

  1. Pfizer Global Research & Development, Groton, CT, USA

Publication History

  1. Published Online: 23 AUG 2010
  2. Published Print: 20 SEP 2010

ISBN Information

Print ISBN: 9780470253175

Online ISBN: 9780470640487

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Keywords:

  • controlled release using bilayer osmotic tablet technology - reducing theory to practice;
  • bilayer osmotic tablets - functional swelling layer and manufactured delivery port;
  • in vitro performance testing - tablet release rate measures, in vitro characterization using dissolution testing

Summary

This chapter contains sections titled:

  • Introduction

  • Overview of Osmotic Pump Devices for Drug Delivery

  • Advantages and Disadvantages of Bilayer Osmotic Tablets

  • Applicability of Bilayer Osmotic Tablet Technology

  • Components of a Bilayer Osmotic Tablet

  • Processing Considerations for Osmotic Tablet Formulations

  • In Vitro Performance Testing

  • Stability Testing

  • Solubilization of Drugs for Osmotic Delivery

  • Summary

  • Acknowledgments

  • References