11. Involvement of Oxidative Stress in Anticholinesterase Pesticide Toxicity

  1. Tetsuo Satoh5,6,7 and
  2. Ramesh C. Gupta8
  1. Dejan Milatovic1,
  2. Michael Aschner1,2,
  3. Ramesh C. Gupta8,
  4. Snjezana Zaja-Milatovic3 and
  5. Gregory Barnes4

Published Online: 28 MAR 2011

DOI: 10.1002/9780470640500.ch11

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

How to Cite

Milatovic, D., Aschner, M., Gupta, R. C., Zaja-Milatovic, S. and Barnes, G. (2011) Involvement of Oxidative Stress in Anticholinesterase Pesticide Toxicity, in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology (eds T. Satoh and R. C. Gupta), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640500.ch11

Editor Information

  1. 5

    Department of Pharmacology and Toxicology, Japan

  2. 6

    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

  3. 7

    HAB Research Institute, Ichikawa, Chiba, Japan

  4. 8

    Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

Author Information

  1. 1

    Vanderbilt University Medical Center, Department of Pediatrics/Pediatric Toxicology, Nashville, TN, USA

  2. 2

    Departments of Pediatrics and Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA

  3. 3

    Vanderbilt University School of Medicine, Department of Cancer Biology, TN, USA

  4. 4

    Vanderbilt University School of Medicine, Department of Neurology, Nashville, TN, USA

  5. 8

    Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

Publication History

  1. Published Online: 28 MAR 2011
  2. Published Print: 18 JAN 2011

ISBN Information

Print ISBN: 9780470410301

Online ISBN: 9780470640500

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Keywords:

  • toxicity and biomonitoring - oxidative stress in anticholinesterase pesticide toxicity;
  • oxidative stress, imbalance - between free radical production and antioxidant defenses;
  • anticholinesterase induced oxidative injury suppression

Summary

This chapter contains sections titled:

  • Introduction

  • Neurotoxic Effects

  • Oxidative Injury and Lipid Peroxidation

  • Role of High-Energy Phosphates and Nitric Oxide (NO/NOS)

  • Dendritic Degeneration Following Anticholinesterase-Induced Excitotoxicity

  • Suppression of Anticholinesterase-Induced Oxidative Injury

  • Conclusions

  • Acknowledgments

  • References