12. Central Mechanisms of Seizures and Lethality Following Anticholinesterase Pesticide Exposure

  1. Tetsuo Satoh4,5,6 and
  2. Ramesh C. Gupta7
  1. Andrzej Dekundy1,2 and
  2. Rafal M. Kaminski3

Published Online: 28 MAR 2011

DOI: 10.1002/9780470640500.ch12

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

How to Cite

Dekundy, A. and Kaminski, R. M. (2011) Central Mechanisms of Seizures and Lethality Following Anticholinesterase Pesticide Exposure, in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology (eds T. Satoh and R. C. Gupta), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640500.ch12

Editor Information

  1. 4

    Department of Pharmacology and Toxicology, Japan

  2. 5

    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

  3. 6

    HAB Research Institute, Ichikawa, Chiba, Japan

  4. 7

    Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

Author Information

  1. 1

    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland

  2. 2

    In Vivo Pharmacology, R+D CNS, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany

  3. 3

    UCB Pharma S.A., CNS Research, Epilepsy Pharmacology, Chemin du Foriest, R9, B-1420 Braine-l'Alleud, Belgium

Publication History

  1. Published Online: 28 MAR 2011
  2. Published Print: 18 JAN 2011

ISBN Information

Print ISBN: 9780470410301

Online ISBN: 9780470640500

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Keywords:

  • central mechanisms of seizures and lethality - following anticholinesterase pesticide exposure;
  • neurotransmitter systems - in seizures and lethality of anticholinesterases;
  • neuroinflammation role in anticholinesterase-induced seizures

Summary

This chapter contains sections titled:

  • Introduction

  • Neurotransmitter Systems Implicated in Seizures and Lethality of Anticholinesterases

  • Role of Neuroinflammation in Anticholinesterase-Induced Seizures

  • Mechanistic Considerations

  • Conclusions

  • References