3. Butyrylcholinesterase: Overview, Structure, and Function

  1. Tetsuo Satoh2,3,4 and
  2. Ramesh C. Gupta5
  1. Oksana Lockridge,
  2. Ellen G. Duysen and
  3. Patrick Masson

Published Online: 28 MAR 2011

DOI: 10.1002/9780470640500.ch3

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

How to Cite

Lockridge, O., Duysen, E. G. and Masson, P. (2011) Butyrylcholinesterase: Overview, Structure, and Function, in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology (eds T. Satoh and R. C. Gupta), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640500.ch3

Editor Information

  1. 2

    Department of Pharmacology and Toxicology, Japan

  2. 3

    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

  3. 4

    HAB Research Institute, Ichikawa, Chiba, Japan

  4. 5

    Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

Author Information

  1. University of Nebraska Medical Center, Eppley Institute, Omaha, NE, USA

Publication History

  1. Published Online: 28 MAR 2011
  2. Published Print: 18 JAN 2011

ISBN Information

Print ISBN: 9780470410301

Online ISBN: 9780470640500

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Keywords:

  • butyrylcholinesterase - overview, structure and function;
  • butyrylcholinesterase function - deduced from knockout mouse;
  • gene deletions, affecting expression of acetylcholinesterase and butyrylcholinesterase

Summary

This chapter contains sections titled:

  • Introduction

  • Name

  • History

  • Why was Butyrylcholinesterase Rather than Acetylcholinesterase Chosen as a Therapeutic?

  • Function of Butyrylcholinesterase Deduced from Studies In People

  • Function of Butyrylcholinesterase Deduced from the Knockout Mouse

  • Function of Butyrylcholinesterase Deduced from the G117H Transgenic Mouse

  • Function of Butyrylcholinesterase Deduced from the AChE Knockout Mouse

  • Function of Butyrylcholinesterase Deduced from Tissue-Specific Deletions of Acetylcholinesterase and Anchor Proteins

  • Function of Butyrylcholinesterase Deduced from Protection Experiments with Purified Butyrylcholinesterase

  • Butyrylcholinesterase in Human Tissues

  • Summary: Functions of Butyrylcholinesterase

  • Structure of Human Butyrylcholinesterase

  • Conclusions and Future Directions

  • Acknowledgments

  • References