6. The Metabolic Activation and Detoxication of Anticholinesterase Insecticides

  1. Tetsuo Satoh2,3,4 and
  2. Ramesh C. Gupta5
  1. Janice E. Chambers,
  2. Edward C. Meek and
  3. Matthew Ross

Published Online: 28 MAR 2011

DOI: 10.1002/9780470640500.ch6

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

How to Cite

Chambers, J. E., Meek, E. C. and Ross, M. (2011) The Metabolic Activation and Detoxication of Anticholinesterase Insecticides, in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology (eds T. Satoh and R. C. Gupta), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470640500.ch6

Editor Information

  1. 2

    Department of Pharmacology and Toxicology, Japan

  2. 3

    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan

  3. 4

    HAB Research Institute, Ichikawa, Chiba, Japan

  4. 5

    Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

Author Information

  1. Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, MS, USA

Publication History

  1. Published Online: 28 MAR 2011
  2. Published Print: 18 JAN 2011

ISBN Information

Print ISBN: 9780470410301

Online ISBN: 9780470640500

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Keywords:

  • metabolic activation and detoxication - of anticholinesterase insecticides;
  • oxon/phosphate phosphorylation - of serine esterases;
  • catalytic detoxication of malathion by carboxylesterases

Summary

This chapter contains sections titled:

  • Introduction

  • Bioactivation of Organophosphorus Insecticides

  • Oxon/Phosphate Phosphorylation of Serine Esterases

  • Catalytic Detoxication of Malathion by Carboxylesterases

  • Detoxication of N-Methyl Carbamates

  • Activation of N-Methyl Carbamates

  • Metabolism of Pyrethroids

  • Interaction of Insecticides of Different Chemical Classes Through Carboxylesterases

  • Conclusion

  • References