Chapter 1. Mitochondrial Dysfunction in Cell Injury and Cardiotoxicity

  1. Giorgio Minotti
  1. Fabio Di Lisa1,
  2. Martina Semenzato1,
  3. Andrea Carpi1,
  4. Sara Menazza1,
  5. Nina Kaludercic1,
  6. Roberta Menabò2 and
  7. Marcella Canton1

Published Online: 9 APR 2010

DOI: 10.1002/9780470660379.ch1

Cardiotoxicity of Non-Cardiovascular Drugs

Cardiotoxicity of Non-Cardiovascular Drugs

How to Cite

Di Lisa, F., Semenzato, M., Carpi, A., Menazza, S., Kaludercic, N., Menabò, R. and Canton, M. (2010) Mitochondrial Dysfunction in Cell Injury and Cardiotoxicity, in Cardiotoxicity of Non-Cardiovascular Drugs (ed G. Minotti), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470660379.ch1

Editor Information

  1. University Campus Bio-Medico, CIR and Drug Sciences, and Alberto Sordi Foundation-Research Institute on Aging, Via Alvaro del Portillo 21, 00128 Rome, Italy

Author Information

  1. 1

    Dipartimento di Scienze Biomediche Sperimentali, Università degli Studi di Padova, Viale G. Colombo 3, 35121 Padova, Italy

  2. 2

    Sezione Biomembrane, Istituto di Neuroscienze del CNR, Università di Padova, 35121 Padova, Italy

Publication History

  1. Published Online: 9 APR 2010
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9780470772744

Online ISBN: 9780470660379



  • mitochondrial dysfunction - cell injury and cardiotoxicity;
  • myocardial function and oxygen supply - mitochondrial substrate degradation;
  • myocardial ischemia - mitochondrial relevance in cardiomyocyte injury;
  • ischemia-induced ETC inhibition - direct consequences;
  • mitochondria-centered mechanisms - cell injury;
  • pharmacological preconditioning - IPC protection


This chapter contains sections titled:

  • Introduction

  • Mitochondrial Relevance Due to Cardiomyocte Dependence on Oxygen Supply

  • Myocardial Ischemia Exemplifies Mitochondrial Relevance in Cardiomyocyte Injury

  • Major Consequences of Ischemia-Induced ETC Inhibition

  • Mitochondria-Centered Mechanisms of Cell Injury

  • Concluding Remarks

  • Acknowledgements

  • References