Chapter 10. Cardiovascular Toxicities of Life-Saving Drugs: Antiviral Therapy

  1. Giorgio Minotti
  1. James J. Kohler and
  2. William Lewis

Published Online: 9 APR 2010

DOI: 10.1002/9780470660379.ch10

Cardiotoxicity of Non-Cardiovascular Drugs

Cardiotoxicity of Non-Cardiovascular Drugs

How to Cite

Kohler, J. J. and Lewis, W. (2010) Cardiovascular Toxicities of Life-Saving Drugs: Antiviral Therapy, in Cardiotoxicity of Non-Cardiovascular Drugs (ed G. Minotti), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470660379.ch10

Editor Information

  1. University Campus Bio-Medico, CIR and Drug Sciences, and Alberto Sordi Foundation-Research Institute on Aging, Via Alvaro del Portillo 21, 00128 Rome, Italy

Author Information

  1. Emory University, Department of Pathology, WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA

Publication History

  1. Published Online: 9 APR 2010
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9780470772744

Online ISBN: 9780470660379



  • cardiovascular toxicities and antiviral therapy;
  • HAART - highly active anti-retroviral therapy - side effects;
  • antiviral drugs - inhibiting pathogenic viruses replication;
  • antiretroviral drug classes - NRTIs, NNRTIs, PIs;
  • NRTIs - nucleoside/nucleotide reverse transcriptase inhibitors;
  • NRTI-associated cardiomyopathy - endocardial diseases;
  • atherosclerosis and anti-retrovirals, associations;
  • NRTI-associated side effects, in HIV patients - myocardial infarction;
  • NRTIs and mitochondrial toxicity


This chapter contains sections titled:

  • Introduction and Overview

  • Antiretroviral Drug Classes (NRTIs, NNRTIs, PIs)

  • Mitochondrial Toxicity of NRTIs

  • NRTI-Associated Cardiomyopathy

  • Atherosclerosis Associated with Anti-Retrovirals

  • NRTI-Associated MI and CHF

  • Conclusions

  • References