Chapter 3. Cellular Mechanisms, Molecular Targets, and Structure–Function Relationships in Drug-Induced Arrhythmias: Antihistamines, Psychoactive Drugs, and Antimicrobial Agents

  1. Giorgio Minotti
  1. Maria Virginia Soldovieri1 and
  2. Maurizio Taglialatela2

Published Online: 9 APR 2010

DOI: 10.1002/9780470660379.ch3

Cardiotoxicity of Non-Cardiovascular Drugs

Cardiotoxicity of Non-Cardiovascular Drugs

How to Cite

Virginia Soldovieri, M. and Taglialatela, M. (2010) Cellular Mechanisms, Molecular Targets, and Structure–Function Relationships in Drug-Induced Arrhythmias: Antihistamines, Psychoactive Drugs, and Antimicrobial Agents, in Cardiotoxicity of Non-Cardiovascular Drugs (ed G. Minotti), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470660379.ch3

Editor Information

  1. University Campus Bio-Medico, CIR and Drug Sciences, and Alberto Sordi Foundation-Research Institute on Aging, Via Alvaro del Portillo 21, 00128 Rome, Italy

Author Information

  1. 1

    Dept. of Health Science, University of Molise, Via De Sanctis, 86100 Campobasso, Italy

  2. 2

    Section of Pharmacology, Dept. of Neuroscience, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy

Publication History

  1. Published Online: 9 APR 2010
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9780470772744

Online ISBN: 9780470660379

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Keywords:

  • drug-induced arrhythmias - antihistamines, antimicrobial agents;
  • cardiac action potential - ionic mechanisms;
  • hemodynamically-efficient contraction - ordered atrial propagation;
  • drug-induced cardiotoxicity - electrocardiographic manifestations;
  • ECG - electrocardiogram - assessing cardiotoxic manifestations;
  • hERG - human ether-a-gogo-related gene;
  • drug-induced arrhythmias;
  • action potential repolarization - hERG currents;
  • antihistamines and cardiac toxicity;
  • psychotropic drugs - pro-arrhythmic actions

Summary

This chapter contains sections titled:

  • Introduction

  • Ionic Mechanisms of the Cardiac Action Potential

  • Electrocardiographic Manifestations of Drug-Induced Cardiotoxicity

  • HERG/IKR as a Molecular Target for Drug-Induced Arrhythmias

  • Biophysical Properties of HERG/IKR

  • Antihistamines and Cardiac Toxicity

  • Pro-Arrhythmic Actions of Psychotropic Drugs

  • Cardiac Toxicity of Antimicrobial Agents

  • Why Is HERG/IKR as a Preferred Target for QT-Prolonging Drugs?

  • Conclusions

  • References