Chapter 5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings

  1. Giorgio Minotti
  1. Joseph R. Carver and
  2. Chaitali J. Desai

Published Online: 9 APR 2010

DOI: 10.1002/9780470660379.ch5

Cardiotoxicity of Non-Cardiovascular Drugs

Cardiotoxicity of Non-Cardiovascular Drugs

How to Cite

Carver, J. R. and Desai, C. J. (2010) Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings, in Cardiotoxicity of Non-Cardiovascular Drugs (ed G. Minotti), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470660379.ch5

Editor Information

  1. University Campus Bio-Medico, CIR and Drug Sciences, and Alberto Sordi Foundation-Research Institute on Aging, Via Alvaro del Portillo 21, 00128 Rome, Italy

Author Information

  1. University of the Sciences in Philadelphia, Hospital of the University of Pennsylvania, 1600 Penn Twr, 3400 Spruce St., Philadelphia, PA 19104, USA

Publication History

  1. Published Online: 9 APR 2010
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9780470772744

Online ISBN: 9780470660379



  • cardiovascular toxicity of antitumor drugs - in adults;
  • cardiotoxicity (CT) - chemotherapy and anti-cancer drugs;
  • anthracyclines - anchor drug of cancer chemotherapy;
  • monoclonal antibodies infusion-associated fever, nausea;
  • antimetabolites - gemcitabine-related cardiovascular toxicity;
  • transmembrane receptor inhibitors - tyrosine kinase inhibitors (TKI)


This chapter contains sections titled:

  • Introduction

  • Anthracyclines and Related Drugs

  • Monoclonal Antibodies

  • Antimetabolites

  • Alkylating Agents

  • Microtubule-Targeting Drugs

  • Immunomodulating Agents

  • Transmembrane Receptor Inhibitors: Small Molecule EGFR/Tyrosine Kinase Inhibitors (TKI)

  • Epidermalgrowth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors

  • Retinoids

  • Proteosome Inhibitors

  • Platinum-Based Chemotherapy

  • Folate Antagonists

  • Cytokines

  • Radioimmunotherapy

  • Miscellaneous Drugs

  • Bone Marrow Transplantation (BMT)

  • Tamoxifen and Aromatase Inhibitors

  • 5-Hydroxytryptamine3 Receptor Antagonists

  • Summary

  • References