Chapter 12. Genetics of Bipolar Disorder

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Falk W. Lohoff1 and
  2. Wade H. Berrettini2

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch12

Bipolar Disorder

Bipolar Disorder

How to Cite

Lohoff, F. W. and Berrettini, W. H. (2010) Genetics of Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch12

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    University of Pennsylvania School of Medicine, Department of Psychiatry Center for Neurobiology and Behavior, Translation Research Laboratories., 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA

  2. 2

    University of Pennsylvania School of Medicine, Room 2206, 125 South 31st Street, Philadelphia, PA 19104, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • genetics of bipolar disorder;
  • search for bipolar disorder (BPD) susceptibility genes;
  • genetic epidemiology of bipolar disorders;
  • linkage studies of bipolar disorder;
  • candidate gene studies of bipolar disorder;
  • sequence variation in human genome - a single nucleotide polymorphism (SNP);
  • model of risk and protective alleles - involved in psych;
  • brain-derived neurotrophic factor (BDNF);
  • serotonin transporter (5HTT);
  • genome-wide association study (GWAS) design


This chapter contains sections titled:

  • Introduction

  • Genetic epidemiology of bipolar disorders

  • Linkage studies of bipolar disorders

  • Candidate gene studies of bipolar disorder

  • Genome-wide association studies

  • Conclusions and future directions

  • References