Chapter 13. Structural Brain Imaging in Bipolar Disorder

  1. Lakshmi N. Yatham4 and
  2. Mario Maj5
  1. Paolo Brambilla1,2 and
  2. Jair C. Soares3

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch13

Bipolar Disorder

Bipolar Disorder

How to Cite

Brambilla, P. and Soares, J. C. (2010) Structural Brain Imaging in Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch13

Editor Information

  1. 4

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 5

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Inter-University Center for Behavioural Neurosciences, Department of Pathology and Experimental and Clinical Medicine, Section of Psychiatry, University of Udine, Udine, Italy

  2. 2

    Scientific Institute, IRCCS ‘E. Medea’, Udine, Italy

  3. 3

    Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • structural brain imaging in bipolar disorder;
  • brain imaging studies, specifically with magnetic resonance imaging (MRI);
  • dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC);
  • subgenual prefrontal cortex (SGPFC);
  • declarative memory, conscious recollection, verbal reflection and expression of facts and events - supported by hippocampus;
  • val-66-met single nucleotide polymorphism (SNP) - in brain-derived neurotrophic factor (BDNF) gene;
  • thalamus, relay station between cortical and subcortical brain regions - crucial for motor and cognitive coordination;
  • basal ganglia, including caudate, putamen and globus pallidus;
  • structural abnormalities, in bipolar disorder - in anterior cingulate, hippocampus, amygdala and corpus callosum


This chapter contains sections titled:

  • Prefrontal cortex

  • Ventricles

  • Limbic structures

  • Subcortical structures

  • Corpus callosum

  • Cerebellum and vermis

  • Conclusions

  • Acknowledgements

  • References