Chapter 17. Molecular Biology of Bipolar Disorder

  1. Lakshmi N. Yatham2 and
  2. Mario Maj3
  1. Ana Andreazza,
  2. Jun Feng Wang and
  3. Trevor Young MD

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch17

Bipolar Disorder

Bipolar Disorder

How to Cite

Andreazza, A., Wang, J. F. and Young, T. (2010) Molecular Biology of Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch17

Editor Information

  1. 2

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 3

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. Department of Psychiatry, University of British Columbia, 2255 Westbrook Mall, Vancouver, BC V6T 2A1, Canada

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • molecular biology of bipolar disorder;
  • bipolar disorder (BD), common, chronic, recurrent mental illness - prevalence of about 1–3% of worldwide population;
  • signal transduction pathways - responsible for coordinating cellular response to information impinging on cell from multiple sources and time frames;
  • abnormalities in pathways - leading to a functional imbalance in multiple neurotransmitter pathways;
  • G-proteins, integral part of intracellular signaling pathway;
  • G-protein coupled dopaminergic receptors, D1 and D2 - associated with BD;
  • signal protein binding in receptor - a second messenger activated;
  • regulation of second messenger GSK-3 by protein kinase B (AKT) and WNT system;
  • BD pathophysiology and treatment implications;
  • signalling pathway modulation - central to understanding neuroplasticity mechanism, mechanisms of action of mood stabilizers


This chapter contains sections titled:

  • Introduction

  • Signal transduction pathways

  • References